Analysis of the algorithm: From rankings to backup genes.

Ranking section

For each of the affected genes present in the list, a ranking with the score and percentile of every possible gene was obtained. Once this was done, the position for every known backup gene was obtained and the statistical descriptor of all the values calculated.

Table 1. Backup position values for every kernel and net before integration.

Net Kernel Elements Min Max Average Standard_Deviation
biological_process ct 70 0.0 0.723 0.079 0.159
biological_process el 70 0.011 0.966 0.618 0.247
biological_process ka 70 0.0 0.698 0.075 0.159
biological_process rf 70 0.0 0.723 0.079 0.159
cellular_component ct 71 0.0 0.868 0.125 0.195
cellular_component el 71 0.005 0.973 0.553 0.282
cellular_component ka 71 0.0 0.886 0.128 0.198
cellular_component rf 71 0.0 0.868 0.125 0.195
disease ct 25 0.001 0.945 0.158 0.277
disease el 25 0.005 0.936 0.22 0.276
disease ka 25 0.0 0.943 0.166 0.295
disease rf 25 0.001 0.947 0.158 0.277
genetic_interaction ct 63 0.0 1.0 0.423 0.327
genetic_interaction el 63 0.0 1.0 0.451 0.333
genetic_interaction ka 63 0.0 1.0 0.937 0.244
genetic_interaction rf 63 0.0 1.0 0.444 0.337
molecular_function ct 71 0.0 0.994 0.148 0.279
molecular_function el 71 0.029 0.958 0.507 0.287
molecular_function ka 71 0.0 0.975 0.151 0.277
molecular_function rf 71 0.0 0.994 0.148 0.279
pathway ct 30 0.001 0.996 0.069 0.18
pathway el 30 0.001 0.185 0.027 0.047
pathway ka 30 0.001 1.0 0.307 0.454
pathway rf 30 0.001 0.157 0.03 0.044
phenotype ct 26 0.0 0.881 0.203 0.273
phenotype el 26 0.03 0.837 0.497 0.194
phenotype ka 26 0.0 0.968 0.221 0.299
phenotype rf 26 0.0 0.882 0.203 0.273
protein_interaction ct 73 0.0 0.741 0.038 0.125
protein_interaction el 73 0.0 0.779 0.039 0.132
protein_interaction ka 73 0.001 1.0 0.347 0.471
protein_interaction rf 73 0.0 0.74 0.037 0.124

Table 2. Backup position values for every kernel after integration

Integration Kernel Elements Min Max Average Standard_Deviation
integration_mean_by_presence ct 73 0.0 0.867 0.118 0.239
integration_mean_by_presence el 73 0.0 0.859 0.199 0.228
integration_mean_by_presence ka 73 0.0 0.794 0.054 0.145
integration_mean_by_presence rf 73 0.0 0.352 0.027 0.063
mean ct 73 0.0 0.857 0.097 0.225
mean el 73 0.0 0.798 0.11 0.178
mean ka 73 0.0 0.565 0.035 0.098
mean rf 73 0.0 0.349 0.034 0.074

CDF plots of non integrated kernels

CDF plots of integrated kernels